doi: 10.1016/j.neuroimage.2003.11.010, Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., et al. doi: 10.1111/j.1471-4159.1992.tb09432.x, Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., et al. Alzheimer's disease (AD) is one of the most disastrous neurodegenerative diseases and the most prevalent cause of dementia in elder population. doi: 10.2174/156720510793611592, Jack, C. R. Jr., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., et al. We categorized subgroups into quartiles (quartile 1, ≤3.4 mg/dL; quartile 2, >3.4 and ≤3.7 mg/dL; quartile 3, >3.7 and ≤4.0 mg/dL; quartile 4, >4.0 mg/dL), as described in previous reports (Dhingra et al., 2007, 2010; Ye et al., 2016). Variables were logarithmically transformed to adjust skewness of the distribution and to normalize variance. Global cerebral amyloid burden was natural log transformed. Mean age was 15.5 years and the mean percent of ideal body weight (IBW) was 72.7%. Overall, 27.5% of patients were treated with phosphorus supplements. To investigate the relationship between serum phosphorus and global cerebral Aβ deposition, partial correlation analysis was used, with correction for the influence by the different covariates (CV; age and sex). 3. Neuroimage Clin. Comparison of serum phosphorus levels between PiB+ and PiB− in whole cognitively impaired subjects (MCI plus ADD, **p < 0.01; P–values were obtained by ANCOVA comparing adjusted mean after controlling for the effect of age and sex, right graph). Furthermore, the multiple regression analyses were conducted in three models (set 1, MCI only; set 2, ADD only; set 3, both MCI and ADD; Table 3). Cell Biol. Introduction. Cardiac symptoms: dyspnea, and orthopnea. Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets. This work was supported by grants from NRF (2015R1A2A1A05001794, 2014M3C-7A1046047, MRC (2011-0030738)); the Education and Research Encouragement Fund of SNU Hospital for IM-J. All statistical analyses were performed using Medcalc 17.2 (Medcalc Software, Ostend, Belgium). AUC value was significantly enhanced by combining the two variables (AUC, 0.757–0.800; Figure 2A, gray and black line; Figure 2B, p = 0.0343, comparison of ROC curves analysis). Soc. Cu2+ affects amyloid-β (1-42) aggregation by increasing peptide-peptide binding forces. Low phosphorus levels may be due to a range of nutritional problems and medical conditions, including: chronic use of antacids lack of vitamin D not getting enough phosphorus in your diet malnutrition alcoholism hypercalcemia, or high serum … The BMI value declines at the preclinical stage but not after the onset of AD (Gu et al., 2014). This study aimed to evaluate the predictive performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of COVID‐19 patients. Table 5. doi: 10.1006/mchj.1995.1013, Andrási, E., Páli, N., Molnár, Z., and Kösel, S. (2005). However, phosphorus was not spared with the numerous other drug and nutrient shortages. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. Table 1. Med. More than a fourth of the group needed phosphorus supplementation, and the authors found that those at greatest risk weighed <70% of IBW. (2013). 31, 211–225. The results with Aβ deposition was compared with the serum levels of phosphorus. Finally, this study was supported by a grant from NRF (2015R1C1A2A01053545) for S-HH. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. They underwent comprehensive KBASE baseline assessment including clinical examination, neuropsychological assessments, neuroimaging, including magnetic resonance imaging (MRI), PiB-PET, and blood tests. Prog. A. Studies have shown that various processes such as energy storage, bone and muscle production, hormonal balance, and brain metabolism require appropriate level of phosphorous (Fiske and Subbarow, 1929; Bourgoignie, 1982; Shi et al., 2003; Takeda et al., 2012; Li et al., 2017). NOTE: This is the Consumer Version. However, given that our results from multiple logistic regression analyses were consistent with those from multiple linear regression analyses, our finding still supports the inverse relationship between serum phosphorus level and cerebral Aβ deposition. Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study. 167, 879–885. doi: 10.1093/brain/awv112, Vural, H., Demirin, H., Kara, Y., Eren, I., and Delibas, N. (2010). Curr. Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients. This development was preceded by increasing interest in the prognostic significance of hyperphosphatemia among patients with end-stage renal disease. doi: 10.1016/S0306-4522(02)00404-9, Zlokovic, B. V. (2011). Neurol. (1998). Greatest risk at very low IBW. doi: 10.1093/eurjhf/hfq106, Dhingra, R., Sullivan, L. M., Fox, C. S., Wang, T. J., D'Agostino, R. B. Sr., Gaziano, J. M., et al. This study aimed to evaluate the clinical performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of patients with coronavirus disease 2019 (COVID‐19). Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. 2. 7, 656–664. Alzheimers. Neuropsychol. Nat. J. Inorg. Figure 1. doi: 10.1097/NEN.0b013e3181919a48, Palop, J. J., and Mucke, L. (2010). J. Med. Serum phosphorus levels and risk of incident dementia. Washington, DC: American Psychiatric Association. A study of serum magnesium, calcium and phosphorus level, and cognition in the elderly population of South India. doi: 10.1093/geronb/gbs077, Querfurth, H. W., and LaFerla, F. M. (2010). Neuroimage 24, 969–979. In addition, serum phosphorus level was correlated with cerebral Aβ deposition even after controlling for serum calcium levels and/or MMSE score with age, sex, and ApoE ε4 types (age, sex, calcium, and ApoE as covariates, β = −0.066 and p < 0.001; age, sex, MMSE score and ApoE as covariates, β = −0.066 and p < 0.001; age, sex, calcium, MMSE score and ApoE as covariates, β = −0.067 and p < 0.001; Table 4). (2005). J. Gerontol. The correlation between serum phosphorus level and cerebral amyloid deposition remained significant even after controlling for the effect of other ions and BMI in the multiple regression model (Table 5). The serum phosphorus content, contrary to the usual occurrence with vitamin D therapy, was depressed, while the urinary excretion of phosphorus was increased. More than a fourth of the group needed phosphorus supplementation, and the authors found that those at greatest risk weighed <70% of IBW. Intracellular phosphorus metabolism of Microcystis aeruginosa under various redox potential in darkness. 19 The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. ©2002 Gürze Books. Bourgoignie, J. J. (2006). Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Amyloid aggregation and AD pathogenesis can be influenced by BMI as well as various ions such as calcium, iron, zinc, and copper are known to be relevant to amyloid aggregation (Miller et al., 2010; Hane et al., 2013; Han et al., 2016). A low blood phosphate level is known as hypophosphatemia; an elevated level is termed hyperphosphatemia. 362, 329–344. doi: 10.1016/j.jalz.2011.03.005, Miller, Y., Ma, B., and Nussinov, R. (2010). doi: 10.1001/archinte.167.9.879. Conclusions: This study supports that low serum phosphorus level is associated with mortality in patients with acute ischemic stroke. Alexand. 9:20. doi: 10.1186/s13195-017-0248-8, Piccinin, A. M., Muniz-Terrera, G., Clouston, S., Reynolds, C. A., Thorvaldsson, V., Deary, I. J., et al. (2010). (1995). 7, 273–284. Only the gray matter (GM) was used for extraction by applying GM mask to each individual in order to exclude white matter and CSF space. Proc. Thedevelopmentofricketsinmanis inthreephases, two of which are associated with a low serum phosphorus concentration (8). Body mass index (BMI) was calculated for all participants from their heights and weights. Multiple regression analyses of phosphorus and global cerebral Aβ deposition. Control of serum phosphorus has become an important clinical priority in contemporary nephrology practice. Association cerebral amyloid deposition with serum phosphorus levels in cognitively impaired subjects (A) Partial correlation plot shows the relationship between global cerebral amyloid deposition (SUVR) and serum phosphorus after controlling for age and sex, in both MCI and ADD (MCI, *p < 0.05; ADD, *p < 0.05). , Y., Ma, B. V. ( 2011 ) relationship between serum levels! 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